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The weight-loss medications have proven to be incredibly effective at helping people lose weight, and they seem to offer many other health benefits as well, like improving heart health and reducing addictive behaviors

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This metabolic symbiosis exhibits biphasic regulation: LNCaP cells upregulate Gln catabolic pathways (e.g., GLS1-dependent glutaminolysis), while CAFs activate extracellular matrix (ECM) remodeling pathways

Elevated CD36 expression or activity signifies a pathogenic enhancement of normally homeostatic clearance mechanisms (1, 15, 31)

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doi:10.1016/j.ctcp.2012.05.002